Endocrine Abstracts

Introduction: The risk of aortic dissection (AoD) is significantly increased (40 per 100,000/y) in women with Turner Syndrome (TS), but the clinical profile and management for those at risk are not well-established. To gain a better understanding, we present the experience of a single centre with multidisciplinary care, including dedicated cardiology, for management of TS in adulthood.Methods: Retrospective case-review of women develop...

Background: Optimization of sex hormone replacement therapy (SHRT) is essential in long-term management of patients with hypogonadism. However, approaches to formulations of therapy, dose change (if any), monitoring of adequacy of therapy and safety are not standardised.Objectives: The survey aimed to establish the approach to management of SHRT for male and female hypogonadism.Methods: Online survey, live for 4 weeks (1/11/2021) d...

Background: Immune checkpoint inhibitors (ICIs), approved in the UK for the treatment of increasingly numerous malignancies, are commonly associated with endocrine sequelae, some of which may be life threatening. Society for Endocrinology guidelines detail management protocols for acute endocrinopathies, however widely accepted standards for their routine detection are lacking. Hypophysitis, clinically and radiologically silent in many, is seen in up to 15% of patients on ICIs...

Introduction/Aim: In Addison’s disease, patient-self maintenance of adequate cortisol levels is essential. Optimising cortisol control is challenging and well documented. Traditional management aims to ensure adequate daily cortisol levels, management of stressful situations/acute illness, avoiding over replacement. Alert dogs are currently used to support patients with hypoglycaemia unawareness. Recent reported international studies of alert dogs in primary and secondary...

Introduction: The risk of maternal death from aortic-dissection(AoD) during pregnancy/post-partum in TS is increased, due to TS-associated risk factors (bicuspid-aortic-valve(BAV), aortic-coarctation, aortic-dilatation, hypertension) and the increased cardiovascular strain of pregnancy itself. TS-guidelines advice against pregnancy in the presence of severe aortic-dilatation or moderate dilatation with AoD-risk factors; and after aortic surgery a high risk remains. However, fe...

Introduction: The management of active thyroid eye disease (TED) remains controversial. High dose intravenous methylprednisolone (IVMP) is the current recommended first-line treatment based on EUGOGO guidance. Such therapy has the potential for serious adverse effects. We present the outcomes of an alternative approach in the management of moderate-to-severely active TED, using steroid-sparing agents (SSAs) in conjunction with IVMP. Methotrexate is used as the first-line SSA a...

Since the introduction of the reduction in hours for junior doctors in 1991, nurse led clinics (NLC) have increasingly become embedded into specialist practice. Whilst some NLC such as Diabetes and Respiratory have been established for many years, in the area of Endocrinology they are a newer evolving concept.Currently there is limited research in this area. An online survey was distributed to 98 nurse members of the Society for Endocrinology. The questi...

Background: Pre-pituitary surgery, patients attend a ‘Pre-Pituitary Surgery Clinic’ (PPSC), to discuss management options and risks. Clinicians in attendance are; pituitary surgeon (1) registrar (1) endocrine team consultants (1–3), registrars (1–2) nurses (1) senior house officer (1) visiting doctors/medical students (4–6). Patients are informed a number of clinicians attend the clinic due to the multidisciplinary nature (MDT) and unit teaching respon...

Background: Thyroid eye disease (TED) is an autoimmune inflammatory disease that can be both disfiguring and potentially sight threatening. Suppression of inflammation in active disease can reduce the risk of visual loss and limit long-term sequelae of the disease. Current disease management involves suppression of inflammation using glucocorticoids. The aim of our study was to evaluate the efficacy of early disease intervention with targeted immunomodulatory therapy to alter ...

Background: Patient Support Groups (PSG) play a key role in the support, education, research and training for patients and clinicians alike, as well as providing invaluable input to key documents e.g. Defining the Future of Endocrinology (DfE), highlighting the importance of a closer working relationship with SfE.About the PSG Network: Established in Sept 2021, the network includes representation from SfE affiliated PSG ...